International Journal of Contemporary Education (ISSN: 2575-3177; E-ISSN: 2575-3185) is an open-access, international, double-blind peer-reviewed journal published by Redfame Publishing. The journal is published Semiannually in both print and online versions and accepts articles submission online or by email. The online version is free to access and download. IJCE aims to promote excellence through dissemination of high-quality research findings, specialist knowledge, and discussion of professional issues that reflect the diversity of this field.
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Then, in the incision site around the sciatic nerve, levobupivacaine (100 μL, 0.05 mg levobupivacaine per mouse) and DMSN-bupi (100 μL, equal 0.05 mg levobupivacaine per mouse) were administered. Following the injection, ultrasound treatment was administered immediately, and behavioral assessments were performed 0.5 hours later. The pain threshold measurement result showed that the incision pain model was established successfully 3 h after surgery because the mechanical threshold and thermal latency decreased (Figure 4A). These mice were randomly assigned to different groups. A group of mice receiving sciatic nerve injections of free levobupivacaine showed a burst and transient pain relief. The mechanical threshold and thermal latency increased at 3 h and gradually converged with the PBS group. 2ff7e9595c
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